Table 1.

Summary of Previously Reported Phenotypes of SRCs in the CNS

Coactivator	Physiologic Function	References
SRC1	Expression higher in males than females	(18, 19)
	Important in HPA axis regulating CRH for glucocorticoid receptor	(21, 22)
	Hypothalamic expression in males decreases during stress	(23)
	Loss increases corticosterone in response to stress	(21, 22)
	Loss impairs motor coordination through developmental Purkinje cell defect	(24)
	Colocalizes with ER and PR in reproductive relevant regions of brain	(26, 27)
	Regulates reproductive behaviors	(28)
	In SF-1 neurons interacts with ERα to regulate feeding behaviors	(29)
SRC2	Colocalizes with ER and PR	(27, 30)
	Expression decreases upon testosterone administration	(30)
	Compensates for loss of SRC1 in the VMN	(28)
	Loss abolishes female reproductive behaviors	(28)
	Ablation decreases corticosterone in males from an adrenal gland insufficiency altering HPA axis	(32)
SRC3	Loss decreases circulating estrogen and IGF-1	(28, 33)
	In the pituitary interacts with PR and increase FSHβ	(14, 34)
	Expression and activity in embryonic neurons changes in response to all-trans retinoic acid	(36)
	Interacts with ERβ	(35)
	In the pituitary activates PR in response to GnRH	(14, 34)
	Decreased endurance from CACT deficiency	(6)

SF-1, steroidogenic factor 1; CACT, carnitine-acylcarnitine translocase.