Figure 1. TRAIL sensitivity and mutation status of human colorectal and non-transformed cell line panel.

Cells were treated for 96 h with TRAIL and cell number was measured by SRB; GI₅₀ for each cell line is represented on the Y axis, >250 ng/ml indicates that the GI₅₀ was not achieved below this concentration. N=3, error bars are standard deviations; (*) denotes N=4 for WIDR and HT29 cell lines. CO841 and CO18 are non-transformed human colon epithelial cell lines while the remaining are cancer lines. Mutation status for KRAS, BRAF and PIK3CA are reported in the lower panel, each circle representing the presence of the mutated form of the protein for each cell line.