Table III.
Differences of CYP3A5-Phenotype- and ABCB1-Genotype-Least-Squares Means Adjustment for Dose- and Weight-Normalized Tacrolimus Trough Concentration and Multiple Comparisons by Tukey–Kramer Post-Hoc Test
| Parameter | Estimate | SE | t value | p value | Adjusted p value |
|---|---|---|---|---|---|
| CYP3A5 phenotypes | |||||
| Expressor vs. non-expressor | −0.3160 | 0.1185 | −2.67 | 0.008 | 0.008 |
| ABCB1 genotypes | |||||
| 3435CC vs. 3435CT | 0.06045 | 0.1042 | 0.58 | 0.5621 | 0.8308 |
| 3435CC vs. 3435TT | 0.4230 | 0.1250 | 3.38 | 0.0008 | 0.0023 |
| 3435CT vs. 3435TT | 0.3626 | 0.09285 | 3.91 | 0.0001 | 0.0003 |