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Transporter function of the derivative mutants of OATP1A2. The transport of 300 nM [3H] estrone sulfate (E3S) in HEK-293 cells transfected with wild-type and derivative mutants of OATP1A2-E184 (a) OATP1A2-D185 (b), OATP1A2-T259 (c), and OATP1A2-D288 (d) (after subtraction of uptake in with mock-transfected control cells). Values are mean ± SE (n = 3). Different from wild type, *p < 0.05; **p < 0.01
