Table II.
Main Anatomical, Physiological, and Biological Parameters Needed for p-PBPK Model and Equations Used to Calculate Parameter Values During Different Gestation Ages (GA) (14)
| Parameter | Unit | Equation |
|---|---|---|
| Today body weight (kg) | kg | TBW = 61.1 + 0.2409 GA + 0.0038 GA2 |
| Cardiac output (CO) | L/h | CO = 301 + 5.916 GA − 0.088 GA2 |
| Total body fat mass (TFM) | kg | TFM = 17.14 + 0.1305 GA + 0.0008 GA2 |
| Weight of the uterus | g | Weight of the uterus = 80 + 8.2931 GA + 0.3546 GA2 |
| Fetal volume | mL | Fetal volume = 0.01 exp(13.604(1 − exp(−0.0702GA))) |
| Placental volume | mL | Placenta volume = 0.0 − 0.0716 + 0.9146 GA2 − 0.0122 GA2 |
| Amniotic fluid | mL | Aminotic fluid volume = 0 + 1.9648 GA − 1.2056 GA2 + 0.2064GA3 − 0.0061 GA4 + 0.00005 GA5 |
| Volume of fetoplacental unit | mL | Fetoplacental volume = Uterus weight + Placenta volume + Fetal volume + Amniotic fluid volume |
| Blood flow of uterine | L/h | Uterine blood flow = 1.71 + 0.2068 GA + 0.0841 GA2 − 0.0015 GA3 |
| Plasma volume | L | Plasma volume = 2.5 − 0.0223 GA + 0.0042 GA2 − 0.00007 GA3 |
| Red blood cell (RBC) volume | L | RBC volume = 1.49 + 0.0098 GA |
| Total blood volume | L | Total blood volume = plasma volume + RBC volume |
| Glomerular filtration rate (GFR) | mL/min | GFR = 114 + 3.2367 GA − 0.0572 GA2 |