Table III.
Fold Change of Gestation Age-Dependent Parameters Used for Four Case Studies in the Developed p-PBPK Model
| Gestation ages (week) | 12a | 24a | 30b | 35.3c | 36a |
|---|---|---|---|---|---|
| Body weight | 1.06 | 1.13 | 1.17 | 1.22 | 1.22 |
| Cardiac output | 1.19 | 1.30 | 1.33 | 1.33 | 1.33 |
| Volume of fetoplacental unit | 5.60 | 25.67 | 43.57 | 61.15 | 63.43 |
| Blood flow of fetoplacental unit | 8.02 | 20.10 | 25.21 | 27.97 | 28.17 |
| Volume of total body fat | 1.09 | 1.18 | 1.23 | 1.27 | 1.27 |
| Total blood Volume | 1.08 | 1.29 | 1.38 | 1.43 | 1.43 |
| GFR (mL/min) | 1.27 | 1.39 | 1.40 | 1.38 | 1.37 |
a12, 24, and 36 weeks are assumed to be the average gestation weeks reported in metaformin case study
b30 weeks is assumed to be the average gestation average gestation week for midazolam and digoxin
cMedian gestation week reported for emtricitabine case study