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. 2013 Oct;23(10):1749–1762. doi: 10.1101/gr.157651.113

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© 2013, Published by Cold Spring Harbor Laboratory Press

This article, published in Genome Research, is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/.

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Figure 5. — Relative fractions of SNVs in different annotated features in the mutants and wild isolates. (A) The fraction of events observed in different annotated features compared with expected is shown for the mutant collection and the wild isolates. To facilitate comparison, the events have been normalized to synonymous mutations in both sets. In the mutant strains only the nonsense mutants are appreciably depressed as a fraction of expected. In contrast, in the wild isolates, nonsense SNVs are even more severely depressed and missense, splice junction, and to some extent even intergenic SNVs are depressed relative to the expected. (B) The fraction of events in different annotated features for a set of essential and nonessential genes is shown for the mutant set and wild isolates. Genes with deletion alleles produced by the The C. elegans Deletion Mutant Consortium (The C. elegans Deletion Mutant Consortium 2012) were divided into essential (lethal) and nonessential (viable) groups. The fractions of events in essential and nonessential genes within the mutant set are quite similar for all features but nonsense SNVs. The same is true for the wild isolates, but as expected from A the overall proportions are reduced.