Table 1.

Guidance cues and local protein synthesis

Guidance cue	Receptor	Effect on protein synthesis	Target mRNA involved in axon guidnace	Response mediated by protein synthesis	Neuron type	Reference
Netrin1	DCC, UNC-5	Induce	β-actin	Attractive	RGC	Campbell and Holt, 2001; Leung et al., 2006; Yao et al., 2006; Welshhans and Bassell, 2011
Sema3A	Neuropilin1, PlexinA	Induce	Rho A NFPC	Repulsive Caudal turn	DRG RGC	Campbell and Holt, 2001; Wu et al., 2005; Leung et al., 2013
Slit2	Robo3	Induce	Cofilin	Repulsive	RGC	Campbell and Holt, 2001; Piper et al., 2006
Ephrin A	EphA	Suppress	ND	Repulsive	RGC	Nie et al., 2010
Ephrin B	EphB	None	None	None	RGC	Mann et al., 2003
Engrailed	ND	Induce	ND	Attractive, Repulsive	RGC	Brunet et al., 2005
BDNF	TrkB	Induce	β-actin	Attractive, Repulsive	Spinal, hippocampal, and cortical	Zhang et al., 1999; Yao et al., 2006; Sasaki et al., 2010
SFRP1	Fz2	Induce	ND	Attractive	RGC	Rodriguez et al., 2005
NGF	TrkA	Induce	Par3, β-actin WAVE1, cortactin, Arp2	ElongationBranching	RGCDRG	Hengst et al., 2009 Spillane et al., 2012
CSPGs	NgR1, 3	Induce	Rho A	Axonal growth inhibition	DRG	Dickendesher et al., 2012; Walker et al., 2012

BDNF, brain-derived neurotrophic factor; SFRP1, secreted frizzled-related protein 1; NFPC, NF-protocadherin; NGF, nerve growth factor; CSPGs, chondroitin sulfate proteoglycans; RGC, retinal ganglion cell; DRG, dorsal root ganglion neuron ND, not determined.