Table 1.
Patient Characteristics
| Patient number | 20 |
| Splenectomized | 12 |
| Nonsplenectomized | 8 |
| Remobilized patients | 4 |
| With prior plerixafor failure | 3: 2 splenectomized, 1 nonsplenectomized |
| With prior G-CSF failure | 1: splenectomized |
| Median age, years (range) | 32 (23–42) |
| Sex, n (M/F) | 15/5 |
| Median weight, kg (range) | 67 (50–84) |
| β-thal genotype | |
| β0/β0 | 5 |
| β+/β+ | 10 |
| β0/β+ | 5 |
| Median ferritin, mg/dl (range) | 678 (65–1318) |
| Chelation | |
| Desferioxamine | 1 |
| Deferiprone | 1 |
| Deferasirox | 3 |
| Deferiprone+desferioxamine | 15 |
| Mean WBCs (×103/μl) baseline | 9.00±3.94 |
| Splenectomized | 11.33±4.00a |
| Nonsplenectomized | 6.31±1.01a |
| Mean PLT counts (×103/μl) baseline | 458±191 |
| Splenectomized | 580±128.95b |
| Nonsplenectomized | 269.25±81.35b |
| Mean CD34+ cells (/μl) baseline | 4.40±2.80 |
| Splenectomized | 4.92±2.99 |
| Nonsplenectomized | 3.00±2.29 |
| Mean spleen volume, baseline (cm3) | 611±290 |
G-CSF, granulocyte-colony stimulating factor; PLT, platelet; WBCs, whole blood counts (total nucleated cells including erythroblasts).
Data are expressed as median (range) or mean±SD.
a
p=0.002, bp=0.000005.