Table 3.

Cumulative Data on Mobilization Parameters

	Plerixafor only—all patients	Preceding single-agent mobilization (plerixafor n=3, G-CSF n=1) of remobilized patients	Plerixafor+G-CSF—remobilized patients
Patient number	17 (10 SPL, 7 non-SPL)	4 (3 SPL, 1 non-SPL)	4 (3 SPL, 1 non-SPL)
Blood CD34+ cells during aphereses/μl	53±37.9a	20.4±12.4b	115.5±13.3a,b
Splenectomized	65.4±44c,d	21.6±14.4e	118.0±15.1d,e
Nonsplenectomized	37.2±19.2c	17	108
Total CD34+ cell yield,×106/kg	6.3±2.2	2.5±1.4f	8.9±2.9f
Splenectomized	6.7±2.4	2.5±1.5g	7.6±1.6g
Nonsplenectomized	5.6±1.8	2.5	12.7
Days of aphereses	1.88±0.33h	2±0.0	1.00±0.0h
CD34+ cell yield per apheresis,×106/kg	3.6±2.0i	1.2±0.7j	8.9±2.9i,j
Total CFCs,×106/kg
CFU-GM	379±189k	n/a	737±134k
BFU-E	257±112l	n/a	496±66l
Failure to reach 6×106 CD34+ cells/kg	6/17 (35%)	4/4 (100%)	0/4 (0%)
Failure to yield >2.5×106 CD34+ cells/kg	2/17 (12.5%)	3/4 (75%)	0/4 (0%)
Max WBCs,×103/μl	31.3±13.6	41.2±28.1	76.5±19.7
Splenectomized	38.9±13m	Plerixafor: 28±17n/G-CSF: 88	82.2±19.7m,n
Nonsplenectomized	20.6±2.9	27	59.5
Platelet counts,×103/μl
Baseline	458±191o	440±139p	455±151q
After leukaphereses	224±109o	176±51.2p	169±23.6q
Spleen volume, cm3
After mobilization	703±302.4	n/a	n/a
% Splenic enlargement over baseline(max)	10.74±13.9	n/a	n/a

SPL, splenectomized; non-SPL, non-splenectomized BFU-E, erythroid burst-forming unit; CFU-GM, colony-forming unit-granulocyte, macrophage.

Data are expressed as mean±SD or absolute and relative frequencies.

^ap=0.003, ^bp=0.00005, ^cp=0.03, ^dp=0.06, ^ep=0.002, ^fp=0.0002, ^g,kp=0.02, ^hp=0.001, ⁱp=0.0003, ^jp=0.002, ^lp=0.007, ^mp=0.006, ⁿp=0.04, ^op=0.0001, ^p,qp=0.01.