FIG. 10.

RNA transcription levels (means±standard deviation [SD]) of 19 mouse genes in the quadriceps muscle of infected C3H mice relative to gene transcription levels in uninfected (sham inoculated) C3H mice during early and late infection. Samples from infected C3H mice were normalized to samples from sham inoculated mice, expressed in comparison to reference genes (18S rRNA, Actb, B2M, and gapDH), and plotted as fold changes for each gene. Bars to the left of the center line indicate reduced relative expression and bars to the right indicate increased relative expression in infected C3H mice compared to sham-inoculated mice. Zero relative expression indicates no expression in infected C3Hmice. Mouse genes not assessed in mice during early infection were CXCL12, CXCL13, CCL21, and IL-21. Transcriptional activity was not detected for chemokines interleukin-17a (IL-17a) and interferon-γ (IFN-γ) in infected C3H and sham-inoculated mice during early and late infection and was not plotted.