Table 3.
Substance P, pmol/min | ω-3 Fatty acids |
Placebo |
||||||
---|---|---|---|---|---|---|---|---|
0 | 2 | 4 | 8 | 0 | 2 | 4 | 8 | |
t-PA activity, IU mL−1 | ||||||||
Non-infused arm | 0.39±0.08 | 0.45±0.09 | 0.54±0.12 | 0.64±0.14 | 0.45±0.07 | 0.52±0.08 | 0.60±0.09 | 0.65±0.11 |
Infused arm | 0.38±0.08 | 0.83±0.16 | 1.12±0.23 | 1.67±0.38 | 0.43±0.07 | 0.78±0.10 | 1.09±0.11 | 1.26±0.15 |
t-PA antigen, ng mL−1 | ||||||||
Non-infused arm | 11.78±1.29 | 12.01±1.0 | 12.69±1.08 | 12.83±1.49 | 13.45±1.40 | 12.93±1.70 | 13.08±1.80 | 12.37±1.27 |
Infused arm | 11.90±1.45 | 13.98±1.33 | 13.63±1.12 | 14.86±1.40 | 12.55±1.10 | 12.85±1.44 | 13.45±1.35 | 13.97±1.55 |
PAI-1 activity, ng mL−1 | ||||||||
Non-infused arm | 1.77±0.53 | 1.84±0.43 | 1.80±0.42 | 1.64±0.45 | 1.44±0.29 | 1.38±0.26 | 1.39±0.47 | 1.34±0.44 |
Infused arm | 2.33±0.86 | 2.18±0.61 | 2.21±0.69 | 1.92±0.63 | 1.69±0.46 | 1.64±0.41 | 1.54±0.39 | 1.49±0.39 |
PAI-1 antigen, ng mL−1 | ||||||||
Non-infused arm | 39.51±9.22 | 40.84±7.08 | 39.99±6.62 | 38.48±5.79 | 45.06±7.09 | 43.33±6.45 | 44.41±6.67 | 44.26±7.03 |
Infused arm | 37.64±8.36 | 38.83±6.25 | 41.71±5.74 | 40.26±7.32 | 48.89±8.25 | 42.65±6.59 | 43.12±6.60 | 40.61±6.46 |
Net t-PA antigen release, ng 100 mL−1 of tissue mm−1 | 0.23±0.51 | −0.28±4.7 | 3.92±1.8 | 8.41±2.94 | −0.87±1.1 | −0.84±2.82 | 0.94±4.22 | 8.10±3.67 |
Mean±SEM. Data analysed using two-way analysis of variance.
Tissue plasminogen activator (t-PA) activity: dose response p<0.0001. ω-3 Fatty acids versus placebo; p=0.83 (infused arm).
t-PA antigen: dose response p=0.7. ω-3 Fatty acids versus placebo; p=0.60 (infused arm).
Plasminogen-activator inhibitor type 1 (PAI-1) activity: dose response p=0.94. ω-3 Fatty acids versus placebo; p=0.17 (infused arm).
PAI-1 antigen: dose response p=0.67. ω-3 Fatty acids versus placebo; p=0.40 (infused arm).
Net t-PA antigen: dose response p=0.02. ω-3 Fatty acids versus placebo; p=0.62 (infused arm).