Figure 1.

Chronic stress impairs AMPAR-mediated synaptic excitation at TA-CA1 synapses. a, fEPSPs recorded in SLM in response to stimuli delivered at a graded series of intensities in Mg²⁺-free saline. Each line represents a series of responses from one slice from control (black) or CUS (gray) rats. Sets of data from representative slices shown above. b, Mean of the slopes of straight line fits to the data in a in control rats (n = 6), CUS rats (n = 6), and CUS rats administered fluoxetine (n = 8) in Mg²⁺-free saline before (left) and after (right) addition of DNQX. c, Mean of the slope of the AMPAR-mediated and NMDAR-mediated components taken from each slice at a stimulation intensity that produced a fiber volley of ∼0.15 mV. d, TA-CA1 fEPSP slope is plotted before and after induction of LTP in slices from control (black, n = 8 slices) and CUS animals (gray, n = 11 slices). *p < 0.05, **p < 0.01.