Figure 4.
Chronic stress impairs consolidation of long-term memory. a, Comparison of the percentage of time spent in the target quadrant during an initial probe trial, after training, in a memory probe trial performed 24 h after the last training trial, and a consolidation probe trial performed 28 d after the memory trial in control (black, n = 7) and CUS (gray, n = 6) rats. There was a significant effect of time (F(3,33) = 23.96, p < 0.001) and a significant interaction (F(3,33) = 3.07, p = 0.042). Post hoc paired t tests revealed no difference between the memory and consolidation probe times in quadrant for control animals (t(5) = 0.2, p = 0.85), but a significant difference for CUS animals (t(6) = 3.44, *p = 0.014). b, There was no difference in swim speeds during the consolidation trial between control and CUS rats. c, The time in target quadrant in the consolidation trial for all animals was correlated with their sucrose preference (left, r(14) = 0.5, p = 0.072) and latency to feed in the novelty-suppressed feeding test (right, r(14) = −0.74, p = 0.002).