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PWL represented as mean D50 ± 95% CI as a function of cumulative injections of morphine in rats treated with (a) vlPAG Vehicle (n = 8), vlPAG Vehicle + sc Morphine (n = 7), and vlPAG LPS (1.7 μg, n = 7 or 5 μg, n = 6), (b) vlPAG Vehicle (n = 10), vlPAG Vehicle + sc Morphine (n = 7), and vlPAG KDO2 (0.5 μg, n = 5; 1 μg, n = 3; or 5 μg, n = 6) and (c) vlPAG Vehicle (n = 7), vlPAG Vehicle + sc Morphine (n = 7), and vlPAG (+)-morphine (5 μg, n = 10).
