TABLE 2.

Unadjusted and Adjusted Odds Ratios for Treatment Resistance by Medication Class in the i2b2 Treatment-Resistant Cohort^a

	Treatment-Resistant Depression
Medication Class	Unadjusted		Model 1b		Model 2c
	Odds Ratio	95% CI	Odds Ratio	95% CI	Odds Ratio	95% CI
Nonsteroidal anti-inflammatory drugs (NSAIDs)  and COX-2 inhibitors and salicylatesd	1.55	1.21–2.00	1.42	1.09–1.85	1.17	0.83–1.64
NSAIDs only	1.74	1.40–2.18	1.56	1.23–1.97	1.31	1.03–1.76
COX-2 inhibitors only	0.83	0.61–1.12	0.89	0.65–1.22	0.78	0.54–1.12
Salicylates only	1.01	0.82–1.25	1.15	0.91–1.47	1.17	0.86–1.59

^aThe reference group for these analyses is treatment responsive. Likelihood-ratio test compared the fit for model 2 > model 1 > unadjusted (p<0.001 for all comparisons).

^bThe model 1 analysis included age, sex, race, and payer.

^cThe model 2 analysis included model 1 variables as well as log-transformed fact count, age-adjusted Charlson comorbidity index, history of hypertension, history of hyperlipidemia, history of myocardial infarction, history of stroke, and history of type 2 diabetes.

^dAnalysis is consistent with that of Warner-Schmidt et al. (3).