TABLE 4.

Unadjusted and Adjusted Odds Ratios for Nonremission by Medication Class in the Sequenced Treatment Alternatives to Relieve Depression Study Cohort^a

	Treatment-Resistant Depression
	Unadjusted		Model 1b		Model 2c
Medication Class	Odds Ratio	95% CI	Odds Ratio	95% CI	Odds Ratio	95% CI
Nonsteroidal anti-inflammatory drugs (NSAIDs)  and COX-2 inhibitors and salicylatesd	1.23	1.06–1.44	1.17	0.99–1.39	1.12	0.94–1.33
NSAIDs only	1.44	1.18–1.75	1.32	1.08–1.62	1.26	1.02–1.55
COX-2 inhibitors only	1.00	0.73–1.39	0.91	0.65–1.28	0.87	0.62–1.23
Salicylates only	1.08	0.84–1.38	1.04	0.80–1.37	1.02	0.77–1.34
Narcoticse	1.54	1.06–2.24	1.44	0.99–2.10	1.26	0.85–1.85
Level 2 (cognitive behavioral therapy) NSAIDs only	2.42	0.85–6.89	2.57	0.89–7.45	2.14	0.70–6.57

^aThe reference group in the analysis is treatment-responsive.

^bThe model 1 analysis includes age, sex, race, ethnicity, treatment setting, insurance type, and baseline Quick Inventory of Depressive Symptomatology–Self Report scores.

^cThe model 2 analysis includes model 1 variables as well as Cumulative Illness Rating Scale scores for neurologic and musculoskeletal symptoms.

^dAnalyses were consistent with that of Warner-Schmidt et al. (3).

^eData are for individuals who did not receive NSAID cotreatment.