Table I. Burn patients and healthy donors enrolled in the study.
| 1. Healthy donors | |||||
|---|---|---|---|---|---|
|
| |||||
| Donor No. | 1 | 2 | 3 | 4 | 5 |
| Sex (M/F) | M | M | F | M | F |
| Age | 35 | 23 | 45 | 26 | 25 |
| IL-10 (pg/ml) | 10 | 40 | 22 | 8 | 15 |
| 2. Acute phase burn patientsa | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| Patient No. | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
| Sex (M/F) | M | M | M | M | M | F | M | F | M | F |
| Age | 54 | 28 | 28 | 8 | 2 | 4 | 4 | 2 | 2 | 2 |
| TBSA burn (%) | 38 | 80 | 80 | 70 | 35 | 40 | 40 | 40 | 36 | 60 |
| 3rd degree (%) | 38 | 80 | 80 | 70 | 35 | 40 | 40 | 40 | 36 | 60 |
| 2nd degree (%) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Days after burn injuryb | 0 | 0 | 0 | 1 | 2 | 3 | 3 | 3 | 3 | 4 |
| IL-10 (pg/ml)c | 120 | 76 | 80 | 145 | 120 | 220 | 180 | 250 | 560 | 868 |
| 3. Chronic phase burn patientsa | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||||||||
| Patient No. | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 |
| Sex (M/F) | M | M | F | M | M | F | F | M | F | F | M | M | M | M | F | M |
| Age | 4 | 50 | 3 | 10 | 15 | 4 | 12 | 14 | 3 | 3 | 4 | 8 | 15 | 3 | 9 | 6 |
| TBSA burn (%) | 42 | 80 | 33 | 61 | 55 | 58 | 49 | 85 | 46 | 52 | 84 | 44 | 53 | 83 | 65 | 65 |
| 3rd degree (%) | 42 | 80 | 33 | 37 | 45 | 58 | 34 | 85 | 46 | 52 | 74 | 37 | 53 | 73 | 65 | 60 |
| 2nd degree (%) | 0 | 0 | 0 | 24 | 10 | 0 | 15 | 0 | 0 | 0 | 10 | 7 | 0 | 10 | 0 | 5 |
| Days after burn injuryb | 14 | 17 | 22 | 24 | 29 | 30 | 212 | 305 | 363 | 434 | 449 | 586 | 694 | 704 | 829 | 1488 |
| IL-10 (pg/ml)c | 620 | 880 | 640 | 440 | 380 | 675 | 646 | 310 | 225 | 145 | 220 | 176 | 120 | 180 | 140 | 120 |
All patients were subjected to our standard therapeutic protocol, including early excision of burn wound, systemic antibiotic therapy, and continuous enteral feeding.
Day of blood sample collection relative to day of injury; day 0 = same day as injury, day 1 = 1 day after injury. Blood samples were taken once from each patient.
The amounts of IL-10 in sera of these patients were measured by ELISA.