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The C-terminal domains (CTDs) of linker histones are intrinsically disordered. The H1 CTD is disordered in the absence of interacting partners. Upon interaction with DNA or other targets in chromatin, the domain adopts a complementary structure. Interaction with other targets may induce alternative structures. Numbers indicate regions deleted in the work of Lu and Hansen (2004). Globular domain adapted from Vila et al. (2002).
