Table 1.
Pharmacokinetic parameters of G-CSF and 3DHSA-G-CSF from noncompartmental analysis.
| Parameter | Unit | G-CSF | 3DHSA-G-CSF |
|---|---|---|---|
| t 1/2 | h | 2.071 ± 0.037 | 3.425 ± 0.098** |
| T max | h | 1.459 ± 0.021 | 2.097 ± 0.128** |
| C max | ng/mL | 2224 ± 1.425 | 2314 ± 280.1 |
| AUC | h·ng/mL | 8511 ± 244.7 | 16339 ± 1316** |
| MRT | h | 3.091 ± 0.113 | 5.550 ± 0.339** |
| Vz/F | mL/kg | 351.1 ± 5.507 | 303.3 ± 17.00** |
| Cl/F | mL/h/kg | 117.5 ± 3.414 | 61.48 ± 5.191** |
Values are expressed as mean ± SD (n = 3).
SC: subcutaneous; t 1/2: terminal half-life; T max: time of maximum concentration; C max: maximum concentration; AUC: area under the curve; MRT: mean residence time; Vz/F: volume of distribution over bioavailability; CL/F: clearance over bioavailability.
The half-life of 3DHSA-G-CSF is longer than G-CSF and showed significant.
**P < 0.01 versus G-CSF.