Table 4.

Genes That Are Differentially Expressed in the MYOC POAG Case Compared With 13 Control Subjects

Gene Symbol	Description	Probe Identification	Fold Change
PENK	Proenkephalin	GI_40254835	7.8
ECRG4	Esophageal cancer related gene 4 protein	GI_14165275	5.5
MGP*	Matrix Gla protein	GI_4505178	8.5
HLA-DPA1	Major histocompatibility complex, class II, DP alpha 1	GI_24797073	5.7
TAGLN*	Sapiens transgelin	GI_12621918	5.3
KRT19*	Keratin 19	GI_40217850	−28.3
FCGBP*	Fc fragment of IgG binding protein	GI_4503680	5.8
BGN*	Biglycan	GI_34304351	6.7
BCAS1	Breast carcinoma amplified sequence 1	GI_4502372	−6.8
TNNT3	Troponin T3, skeletal, fast	GI_5803202	−7.0
SLPI*	Secretory leukocyte protease inhibitor (antileukoproteinase)	GI_15834622	−7.1
CALML3*	Calmodulin-like 3 (CALML3)	GI_36031099	−14.5
GUCY1A3	Guanylate cyclase 1, soluble, alpha 3	GI_4504212	5.1
ALDH3A1	Aldehyde dehydrogenase 3 family, memberA1	GI_22907048	−10.7
PAX6	Paired box gene 6 (aniridia, keratitis)	GI_4505614	−7.4
KRT13*	Keratin 13	GI_24234693	−7.6
LCN2*	Lipocalin 2 (oncogene 24p3)	GI_38455401	−7.0
S100A9*	S100 calcium binding protein A9 (calgranulin B)	GI_9845520	−8.2
TGM1*	Transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)	GI_4507474	−5.0
IMUP	Immortalization-upregulated protein	GI_27485203	−8.2
KRT15*	Keratin 15	GI_24430189	−11.0
IMUP	Immortalization-upregulated protein	GI_41281602	−5.6
S100A*	S100 calcium binding protein A8 (calgranulin A)	GI_21614543	−8.4
KRT14*	Keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner)	GI_15431309	−5.4

Because of the limited sample size of the MYOC case (two eyes in one patient), we only reported the top genes with the largest relative fold changes (at least 5-fold upregulation or less than −5 fold downregulation) without P values.

^*These genes have been reported as exosome components according to the database from ExoCarta (www.exocarta.org in the public domain).