Fig. 4.

Loss-of-function mutations. The position of loss-of-function mutations are highlighted on the Ca_v1.4 channel model. Panel A displays a view on the channel from the cell exterior, while panel B shows the channel from the cytosolic site with a focus on the central S6 helices. Loss-of-function mutations described for Ca_v1.4 are shown in red. The position of the insertion mutation in Ca_v1.3 at position 403_404 is highlighted in magenta by the corresponding residue G369 in Ca_v1.4.