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Gain-of-function mutations. The gain-of-function mutations are highlighted in green on the Cav1.4 channel model. Panel A shows a side view of the transmembrane domain of the channel, while in panel B the cytosolic side of the channel is exposed. The three gain of function mutations of Cav1.4 are shown in dark green, while residue G373, corresponding to G402 in Cav1.2, is shown in light green.
