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. 2013 Apr;1828(4):1214–1221. doi: 10.1016/j.bbamem.2012.12.016

Fig. 6.

Fig. 6

Primary structure alignment of the four GIRK subunit isoforms at the protein level.

S/Ts in the GIRK4 sequence are highlighted in grey (italics: no major effect on phosphorylation in-vitro; italics/bold: major effect on phosphorylation in-vitro, but no functional consequence) or black (both profound effect on phosphorylation in-vitro and on heterologous facilitation). S/Ts that have been found to be important for heterologous facilitation in the GIRK1 sequence are also highlighted in black [25]. S191 that has been reported to be responsible for PKC regulation is marked in darker grey (both GIRK1 and GIRK4; [36]). Arrows indicate the truncations of the C-terminus used for phosphorylation in vitro (suppl. Figs. S1). TM1, TM2 and P denote the trans membrane and the pore helices, respectively.

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