Fig. 6.
The CCCH zinc finger of Mdlc is crucial for CNS function whereas the RING finger is dispensable. (A) The protein truncations used in misexpression and rescue experiments. (B) Quantification of clone size in rescue experiments. The time between clone induction and brain dissection was 96 hours. Control and mdlc- clone sizes are given as references. *P<0.01, **P<10-3; NS, not statistically different. (C) Quantification of EdU cells per clone (8-hour EdU incorporation), Pros- neurons per clone and ectopic Dpn+ cells per clone in rescue experiments. Expression of MdlcFL, RNF113A or MdlcΔRING rescues all of these phenotypes whereas expression of MdlcΔCCCH or MdlcΔCCCH+RING fails to rescue. Error bars indicate s.d.