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. 2013 Oct;142(4):381–404. doi: 10.1085/jgp.201311015

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© 2013 Vocke et al.

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Figure 11. — The RCBM sequence, segment c, and the homologous regions in the ANO family. (A) Alignment of the distal part of the N-terminal region for the ANO protein family in rat (r). The blue bar marks the RCBM sequence in ANO 1 and ANO 2. Regions encoded by the local exons are printed in red, the RCBM sequence is underlined in green. Percent identity: black = 100%; dark gray = 80%; light gray = 60%. (B) Phylogenetic tree of rat and zebrafish (z) ANO RCBM sequences illustrates a close similarity between the ion channel forming homologues ANO 1 and ANO 2 of fish and mammals. (C) Sequence alignment of the ANO region surrounding segment c in ANO 1 and ANO 2 illustrates the absence of that segment in ANO 3–10.