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. 2013 Oct;142(4):381–404. doi: 10.1085/jgp.201311015

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© 2013 Vocke et al.

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Figure 3. — Inactivation of ANO 2 currents. (A) Current-to-voltage (I/V_m) relations, obtained from 14 consecutive 1-s voltage ramps recorded at 5-s intervals from an ANO 1–expressing cell show a slow decline of whole-cell current in the absence of Cl⁻ depletion. (B) The same experimental protocol reveals a faster current decline in a cell expressing ANO 2 channels. (C) Over the 80-s duration of the experiment, the current rectification ratio (I_{+70 mV}/I_{−70 mV}) steadily increased in ANO 2, but remained near unity (no rectification) in ANO 1. (D) The time course of current decline at the indicated voltages reveals a slow inactivation process in ANO 1, with ∼10% loss over 80 s. (E) In an ANO 2–expressing cell, the time course of current decline illustrates almost complete inactivation within 60 s. (F) The time constant of the single-exponential decay of ANO-2 currents was voltage dependent (means of five cells). Error bars indicate mean ± SEM.