Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Oct;142(4):367–380. doi: 10.1085/jgp.201310986

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2013 Combs et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 6. — Effects of high Mg²⁺ and the Na_Vβ1 subunit on SMase D sensitivity of Na_V channels. (A and B) rNa_V1.4α + β1’s I-V curves (A) and inactivation time courses at −20 mV (B), collected in the presence of 10 mM of extracellular Mg²⁺ without (open squares) or with (closed circles) SMase D; all data are presented as means ± SEM (n = 3). (C–G) Currents of hNa_V1.4α (C), hNa_V1.4α + β1 (D), hNa_V1.5α (E), hNa_V1.5α + β1 (F), and mutant hNa_V1.4α containing hNa_V1.5α’s S5–S6 linkers (G), elicited by depolarizing the membrane from −120 to −20 mV before (black) and after (maroon) SMase D treatment. Dashed lines indicate the zero current level.