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Mode of action of TAS-114C. 5-FU is rapidly degraded by DPD. Therefore, 5-FU-based drugs without a DPD inhibitor (i.e. capecitabine) need massive dosing for cancer treatment although this may cause a higher incidence of HFS. Combination with TAS-114 could reduce the dose of capecitabine by DPD inhibition while maintaining adequate tumor 5-FU levels. On the other hand, the antitumor activity of capecitabine may increase by dUTPase inhibition.
