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. 2011 Aug 22;1(1):36–44. doi: 10.1016/j.rinim.2011.08.001

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© 2011 Published by Elsevier B.V.

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Fig. 4 — The percentage of CD4⁺CD25⁺CD127^lo/− Treg in the CD4⁺ fraction (a), was lower in T1D compared to healthy individuals (p<0.05). Lower CD4⁺CD25⁺CD127^lo/− quota in T1D were also true comparing CD4⁺CD25⁺CD127^lo/− to CD4⁺CD25⁻ (b) (p<0.01). Further, T1D was associated with significantly higher percentages of (c), compared to both healthy (p<0.0001) and high-risk (p<0.01) individuals. T1D was also associated with a lower percentage of the total CD4⁺CD25⁺ cell count (d), compared to the one seen in healthy individuals (p<0.05) and also tended to compared to the individuals at high risk of developing the disease (p<0.1) Moreover, T1D was associated with lower fractions of CD25⁺CD127⁺ (e) in the CD4 positive population, when compared to healthy individuals (p<0.05).