Table 4.
Mean ± standard deviation values of confocal scanning laser ophthalmoscopy parameters with areas under the receiver operating characteristic curves and sensitivities at fixed specificities for discriminating between preperimetric glaucoma and control groups
| Parameter | Glaucoma (n=48) | Control (n=86) | P Value* | AUC (SE) | Sensitivity (Specificity = 80%) | Sensitivity(Specificity = 95%) |
|---|---|---|---|---|---|---|
| Rim area (mm2) | 1.20 ± 0.05 | 1.38 ± 0.03 | < 0.001 | 0.72 (0.05) | 41.8% | 10.4% |
| Rim volume (mm3) | 0.30 ± 0.02 | 0.38 ± 0.01 | 0.002 | 0.71 (0.05) | 52.3% | 11.6% |
| Linear cup-to-disk ratio | 0.59 ± 0.02 | 0.52 ± 0.01 | 0.002 | 0.66 (0.05) | 41.6% | 25.0% |
| Cup-to-disk area ratio | 0.36 ± 0.02 | 0.28 ± 0.01 | 0.003 | 0.66 (0.05) | 41.6% | 22.9% |
| Rim-to-disk area ratio | 0.63 ± 0.02 | 0.71 ± 0.01 | 0.003 | 0.66 (0.05) | 29.0% | 6.9% |
| RNFL CSA (mm2) | 1.07 ± 0.07 | 1.29 ± 0.05 | 0.005 | 0.65 (0.05) | 38.3% | 17.4% |
| Global GPS | 0.54 ± 0.05 | 0.38 ± 0.03 | 0.006 | 0.64 (0.05) | 45.8% | 16.6% |
| Mean RNFL thickness (mm) | 0.22 ± 0.01 | 0.26 ± 0.01 | 0.004 | 0.64 (0.05) | 36.0% | 9.3% |
| Cup area (mm2) | 0.78 ± 0.08 | 0.59 ± 0.04 | 0.023 | 0.62 (0.06) | 37.5% | 18.7% |
| Cup volume (mm3) | 0.24 ± 0.04 | 0.14 ± 0.01 | 0.016 | 0.62 (0.05) | 35.4% | 16.6% |
| Mean cup depth (mm) | 0.28 ± 0.02 | 0.25 ± 0.01 | 0.071 | 0.58 (0.06) | 33.3% | 10.4% |
RNFL = retinal nerve fiber layer
AUC = area under the receiver operating characteristic curve
SE = standard error
RNFL CSA = retinal nerve fiber layer cross sectional area
Global GPS = global glaucoma probability score
*
For comparison of mean values of confocal scanning laser ophthalmoscopy parameters between glaucomatous and control eyes