Figure 5.

Relationship between normalized permeability coefficients (Ph/D) of human sclera and molecular weights of the permeants. The normalized permeability coefficients were calculated by multiplying the steady-state permeability coefficients (P) to sclera thicknesses (h) and then divided by the free aqueous diffusion coefficients (D) of the permeants. The normalized permeability coefficients are related to the hindrance factors according to Eq. 4. The permeability coefficient data of urea and atenolol are obtained from a previous study²² and their diffusion coefficients were calculated using Stokes–Einstein equation with the correction according to Beck and Schultz.²⁹ Symbols: closed square, bevacizumab; closed triangle, ranibizumab; closed circle, FITC-BSA; open circle, FITC-ficoll 70 kDa; open diamonds, FITC-dextrans 20, 40, and 150 kDa; crosses, urea and atenolol. Data represent the mean and standard deviation of at least three sclera samples for each permeant.