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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Exp Neurol. 2013 Aug 19;248:482–490. doi: 10.1016/j.expneurol.2013.08.004

Figure 4. The expression of BACE1 is regulated at the transcriptional level in neurons cultured in conditioned media from astrocytes.

Figure 4

(A) The mRNA expression of BACE1 in neurons treated with CM-B (control) or CM-P, or CM-P plus actinomycinD (ActD) for 12hr. Then the mRNA was extracted and mRNA levels were detected by real-time PCR. (B) Representative western blot results of BACE1 level in control cells (CM-B), in cells treated with CM-P, in cells treated with CM-P in the presence of ActD (1μg/ml) for 12hr (n=3). *p<0.05, **p<0.01, ***p<0.001. A line indicates comparison between the 2 bars connected by the line.