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DISC1/GSK3 signaling involved in regulating neuroplasticity and its regulation. While lithium inhibits GSK3 both indirectly and directly, CHIR-99021 is an ATP competitive inhibitor of GSK3 that mimics the cellular and behavioral effects of lithium. AKTI-17 is an allosteric inhibitor of AKT that blocks the ability of lithium to modulate TCF/LEF–mediated transcription and behavior but not the effect of CHIR-99021.
