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. Author manuscript; available in PMC: 2014 Sep 23.
Published in final edited form as: Vaccine. 2013 Aug 6;31(41):4569–4577. doi: 10.1016/j.vaccine.2013.07.057

Fig. 2.

Fig. 2

Comparison of virulence in the intranasal challenge model.

Groups (n=5) of 5- to 6-weeks-old female mice (BALB/c C57BL/6 and ICR-SCID) were infected intranasally with 106 PFU of MVA, rMVA 44/47.1 and rMVA 51.1, Ankara and ACAM2000 viruses. The uninfected group was mock infected with diluents. Animals were monitored daily for weight loss and death for 47 days although only 14 are shown in the figure. Error bars indicate standard error. Asterisks in BALB/c and 57BL/6 groups indicate numbers of mice infected with Ankara that were sacrificed due to weight loss >30%. In ICR-SCID mice group infected with Ankara, the asterisks refer to two deaths and three sacrificed mice. One ACAM2000-infected SCID mouse was sacrificed due to weight loss >30% at day 47. The postmortem was positive for ACAM2000 virus.