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. Author manuscript; available in PMC: 2014 Sep 23.
Published in final edited form as: Vaccine. 2013 Aug 6;31(41):4569–4577. doi: 10.1016/j.vaccine.2013.07.057

Fig. 3.

Fig. 3

Comparison of virulence in intracranial challenge model. (A) Five- to six-weeks-old female BALB/c mice were infected intracranially with 106 PFU of MVA (n=10), rMVA 44/47.1 (n=15) and rMVA 51.1 (n=15) and ACAM2000 (n=15) viruses. The weight control group was mock infected with diluents. Animals were monitored daily for weight loss for 21 days with no deaths. The data shown are combined from two independent experiments. Error bars indicate standard error. (B) Experimental details are the same as in panel A except that the mice were infected with 107 pfu of MVA (n=15), rMVA 44/47.1 (n=15) and rMVA 51.1 (n=15) and ACAM2000 (n=15) viruses. (C) All 15 mice infected with ACAM2000, 14 mice infected with rMVA 44/47.1, 10 mice infected with rMVA 51.1 and 1 mouse infected with MVA were sacrificed on days 4 – 5 due to >30% loss of starting weight.