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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Neuropharmacology. 2010 Oct 29;60(0):1017–1041. doi: 10.1016/j.neuropharm.2010.10.022

Fig. 1.

Fig. 1

Modular structure of mGlu receptors. a) Ribbon view of the open (left) and closed (right) mGlu1 receptor Venus Fly Trap (VFT) bound with glutamate (back). Images were prepared using the coordinates of the glutamate-bound mGlu1 receptor VFT dimer (pdb 1EWK), in which one VFT is closed while the other is open. b) Side view of the mGlu1 receptor dimer bearing the VFT in its empty “resting” state (left) (pdb 1EWT), or agonist occupied “active” orientation (right) (pdb 1EWK). The front VFT is in light grey, while the one in the back is black. c) General organization of an mGlu receptor deduced from the structure of the dimeric mGlu3 extracellular domain (VFT + CRD) (pdb 1E4U) associated with two rhodopsinlike 7-TM domains.