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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Neuropharmacology. 2010 Oct 29;60(0):1017–1041. doi: 10.1016/j.neuropharm.2010.10.022

Fig. 3.

Fig. 3

Synaptic distribution of group-II and group-III mGlu receptors. Note that presynaptic mGlu2/3 receptors are located in the pre-terminal regions of the axons, where they can be activated by glutamate released from astrocytes via the cystine/ glutamate antiporter. In contrast, presynaptic mGlu4/7/8 receptors are located near to the active zone of neurotransmitter release. Glial mGlu3 receptors induce the formation and secretion of TGF-β. The presence of mGlu5 receptors in glial cells is also shown.