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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Neuropharmacology. 2010 Oct 29;60(0):1017–1041. doi: 10.1016/j.neuropharm.2010.10.022

Table 1.

Conformations of the Venus Fly Traps of mGlu receptor subtypes bound to agonists or antagonists.

Receptor Ligand Ligand activity Conformation PDB entry
mGlu1 – – Dimer Roo 1EWT
– – Dimer Aco 1EWV
Glu Agonist Dimer Aco 1EWK
Glu + Gd3+ Agonist Dimer Acc 1ISR
MCPG Antagonist Dimer Roo 1ISS
LY341495 Antagonist Dimer Aoo 3KS9
mGlu5 Glu Agonist Dimer Acc 3LMK
mGlu3 Glu Agonist Dimer Rcc 2E4U
DCG-IV Agonist Dimer Rcc 2E4V
1S,3S-ACPD Agonist Dimer Rcc 2E4W
1S,3R-ACPD Agonist Dimer Rcc 2E4X
2R,4R-APDC Agonist Dimer Rcc 2E4Y
mGlu7 – – Dimer Roo 2E4Z
LY341495 Antagonist Monomer open 3MQ4

Glu = Glutamate; R = resting; A = active; o = open; c = closed.