Table 1.
Senescence and aging genes in irradiated lung*
| Gene signature | Genes in category | DE, No. | EF | OR (95% CI) | P |
|---|---|---|---|---|---|
| AGEMAP adrenal | 10 | 6 | 1.51 | 2.28 (0.54 to 11.01) | .21 |
| AGEMAP cerebellum† | 13 | 5 | 1.05 | 1.09 (0.27 to 3.98) | 1.00 |
| AGEMAP eye† | 159 | 65 | 1.13 | 1.24 (0.88 to 1.74) | .20 |
| AGEMAP gonads† | 31 | 10 | 1.10 | 1.01 (0.41 to 2.42) | 1.00 |
| AGEMAP heart† | 9 | 3 | 0.84 | 0.76 (0.12 to 3.56) | 1.00 |
| AGEMAP spinal cord† | 37 | 20 | 1.40 | 1.91 (0.94 to 3.93) | .06 |
| AGEMAP spleen† | 18 | 5 | 0.79 | 0.69 (0.19 to 2.16) | .61 |
| AGEMAP thymus† | 183 | 82 | 1.14 | 1.25 (0.92 to 1.7) | .15 |
| AGEMAP lung† | 52 | 28 | 1.44 | 2.03 (1.11 to 3.77) | .02 |
| DASS‡ | 12 | 8 | 2.02 | 6.09 (1.22 to 58.81) | .02 |
| mSS‡ | 16 | 9 | 1.89 | 4.57 (1.14 to 26.25) | .02 |
| DASS + mSS | 28 | 17 | 1.95 | 5.18 (1.83 to 17.98) | <.001 |
| DASS + mSS + lung | 77 | 45 | 1.60 | 2.65 (1.60 to 4.47) | <.001 |
* P values were calculated by Fisher exact test for the comparison between treatments. All statistical tests were two-sided. CI = confidence interval; DASS = DNA damage-associated senescence; DE = number of genes from each signature or category with differential expression (P < .05) across treatments in the array dataset; EF = enrichment factor, a parameter that estimates the extent to which genes identified in the published gene categories are overrepresented in the pool of genes (P < .05) that show changes in expression in the microarray data; mSS = modified secretory senescence signature; OR = odds ratio, odds of enrichment of the specified gene set or category within the pool of genes (P < .05) that show changes in expression in the microarray data versus all genes in the array dataset.
† Genes from the AGEMAP database (5) evaluated in the microarray dataset.
‡ DASS and mSS signatures (6) evaluated in the microarray dataset.