Table 3.
Likelihood (χ2) for distant recurrence for all scores according to subgroup*
| Scores | 0 to 5 years | 5 to 10 years | 0 to 5 years | 5 to 10 years | ||||
|---|---|---|---|---|---|---|---|---|
| Univariate | Multivariable | Univariate | Multivariable | Univariate | Multivariable | Univariate | Multivariable | |
| χ2 (P) | χ2 (P) | χ2 (P) | χ2 (P) | χ2 (P) | χ2 (P) | χ2 (P) | χ2 (P) | |
| Node-negative (n = 683) | Node-positive (N=257) | |||||||
| CTS | 28.47 (<.001) | — | 15.23 (<.001) | — | 29.11 (<.001) | — | 29.63 (<.001) | — |
| IHC4 | 41.50 (<.001) | 27.19 (<.001) | 5.85 (.02) | 1.98 (.20) | 3.51 (.06) | 1.38 (.20) | 5.98 (.01) | 6.05 (.01) |
| RS | 25.24 (<.001) | 14.52 (<.001) | 4.15 (.04) | 1.01 (.30) | 2.94 (.09) | 0.81 (.40) | 8.19 (.004) | 5.17 (.02) |
| ROR | 29.44 (<.001) | 10.41 (.001) | 19.91 (<.001) | 8.93 (.003) | 6.60 (.01) | 1.33 (.20) | 14.79 (<.001) | 8.37 (.004) |
| HER2-negative (n = 845) | ||||||||
| CTS | 70.03 (<.001) | — | 63.44 (<.001) | — | ||||
| IHC4 | 25.35 (<.001) | 14.61 (<.001) | 10.13 (.001) | 5.67 (.02) | ||||
| RS | 20.85 (<.001) | 10.35 (.001) | 6.98 (.008) | 2.81 (.09) | ||||
| ROR | 30.45 (<.001) | 8.69 (.003) | 39.21 (<.001) | 18.18 (<.001) | ||||
| HER2-negative/node-negative (n = 615) | HER2-negative/node-positive (n = 230) | |||||||
| CTS | 14.06 (<.001) | — | 20.12 (<.001) | — | 28.67 (<.001) | — | 24.15 (<.001) | — |
| IHC4 | 19.23 (<.001) | 12.06 (<.001) | 9.97 (.002) | 3.89 (.05) | 7.58 (.006) | 3.94 (.05) | 1.86 (.2) | 1.44 (.20) |
| RS | 13.52 (<.001) | 6.84 (.008) | 7.99 (.005) | 2.23 (.1) | 7.73 (.005) | 4.01 (.05) | 1.57 (.2) | 0.38 (.50) |
| ROR | 19.65 (<.001) | 8.61 (.008) | 28.73 (<.001) | 13.85 (<.001) | 7.82 (.005) | 1.96 (.20) | 8.28 (.004) | 4.78 (.03) |
* Both univariate and multivariable analyses are presented for years 0 to 5 and years 5 to 10 separately. Likelihood ratio test based on Cox proportional hazard models for univariate and multivariable analyses. Changes in likelihood ratio values (χ2) were used. Immunohistochemical markers (IHC4), recurrence score (RS), and risk of recurrence (ROR) are singly added to the clinical treatment score (CTS) for the multivariable models. LR = likelihood ratio; LR-X2 for all scores were done by sample splitting. All statistical tests were two-sided. All scores are continuous variables.