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. 2013 Oct 1;8(10):e75983. doi: 10.1371/journal.pone.0075983

Figure 6. HDM extract prevents LPS-induced expression of Th1-immune response factors in MH-S cells through a TLR2 dependent mechanism.

Figure 6

(A) Inhibition of the LPS-stimulated induced MH-S cells IL-12 production by the TLR2 agonists (see legend figure 5 for experimental details; statistical analysis was performed using Student’s t-test; ** p<0.01; *** p<0.005). (B) HDM extract inhibition of LPS-induced T-bet expression in MH-S cells. MH-S cells were treated as above except that T-bet expression was evaluated by RT-PCR amplification at 2h and 6h post LPS addition. (C) Suppression by TLR2 antibodies of the inhibitory effect of the TLR2 ligands on the LPS induced T-bet expression (TLR ligands are used at the higher inhibitory concentration tested in B).