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. 2013 Oct 1;8(10):e76103. doi: 10.1371/journal.pone.0076103

Figure 4. Histological analysis of tissue engineered grafts in each group at different time points.

Figure 4

A, D, G, J: autologous rASCs+PLGA group; B, E, H, K: PLGA group; C, F, I, L: Only defect group; A-F: 12 week; G-L: 24 week. HE stained histological sections showed that the corneal epithelial cells and endothelial cells were intact in all groups. Corneas in the group with implantation of autologous rASCs-PLGA had been repaired by newly formed tissue, forming more native structures at 24 weeks than at 12 weeks post transplantation. In PLGA alone and only defect group, collagen remodeling was not successful. Corneas were thinner, collagen arrangement was not in good order, and scars existed (A-C, G-I: Magnification ×100; D-F, J-L: Magnification ×200)..