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. 2013 Oct 1;8(10):e76103. doi: 10.1371/journal.pone.0076103

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© 2013 Ma et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A, B: the rASCs+PLGA group autologous; C: PLGA group; D: Only defect group; A: 12 weeks post-implantation; B-D: 24 weeks post-implantation. (E) Distribution and diameter of collagen fibrils in normal cornea. Electron microscopic examination showed larger interfibrillar interval existed in the neoformative stromal matrix (arrow in Figure 5A) at 12 weeks, while normal lamellae containing regularly spaced fibrils formed at 24 weeks. Fibril diameter analysis showed neoformative stroma regained the identical diameter distribution of collagen fibrils to those of normal rabbit corneas in auto-rASCs group at 24 weeks (F) (Magnification ×12000)..