Shown are times of major changes in the evolution of highly pathogenic H5N1, goose/Guangdong-lineage. Expansion into different geographical areas is depicted, as is status in various hosts in different locations: solid lines depict stable interactions between virus and hosts and dashed lines depict transient interactions. Blue lines represent aquatic poultry hosts, green lines terrestrial poultry hosts, and red lines wild birds hosts. SE Asia – South East Asia, Gs/GD - goose/Guangdong, HK – Hong Kong.