Table 1.

Structure and growth-inhibitory activity of ITC and related compounds against B. cereus.

#	Structure	MIC, μg ml−1		Synthetic protocol
		E. coli	B. cereus
Aliphatic ITC derivatives
8.	CH3-NCS	>128	128	*
22.	CH2=CH-CH2 –NCS	>128	128	*
7.	CH3CH2CH2CH2-NCS	>128	128	*
Hydroxy- ITC derivatives
18.	HO -(CH2)4–NCS	>128	16	*
5.	HO -(CH2)5–NCS	>128	16	*
21.	HO -(CH2)6–NCS	>128	16	*
44.	HO -(CH2)7–NCS	>128	16	*
45.	HO -(CH2)8–NCS	>128	8	I
Charged ITC derivative
6.	−2O3PO -(CH2)5 -NCS	128	>128	III
Bifunctional ITC derivatives
38.	SCN -(CH2)4 –NCS	>64	2	I
39.	SCN -(CH2)5 –NCS	>64	2	I
40.	SCN -(CH2)6 –NCS	>64	2	I
41.	SCN -(CH2)7 -NCS	>64	2	I
42.	SCN -(CH2)8 -NCS	>64	2	I
43.	SCN-[(CH2)2 -O-]2 -(CH2)2 -NCS	>64	4	I
37.		8	0.5	I
16.		64	2	I
Aromatic and heterocyclic ITC derivatives
4.		>128	>128	*
1.		64	16	*
17.		>128	16	*
3.		>128	64	*
2.		64	8	*
20.		128	8	*
27.		>128	16	I
19.		>128	8	I
34.		>128	8	II
29.		>128	>128	II
30.		>128	8	II
31.		>128	4	II
32.		128	8	II
35.		>128	8	I
14.		>128	64	**
33.		>128	0.5	I
Control compounds
23.		>128	>128	**
25.		>128	>128	**

^*Known compounds