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. 2013 Oct 1;8(10):e76259. doi: 10.1371/journal.pone.0076259

Figure 1. TCDD reduces parasite burdens and slows the progression of cutaneous leishmaniasis in BALB/c mice.

Figure 1

Female BALB/c mice were treated with peanut oil (vehicle) or TCDD at various doses (per os) one day prior to infection with one million stationary phase L. major promastigotes in one rear footpad. Data are shown for 3-5 mice per treatment group on days 2-35 and are representative of three independent experiments. Data for two mice from one experiment are shown after day 35. (A) Lesion size is shown as mean ± SEM. Symbols with internal plus marks (+) indicate a statistically significant difference from vehicle-treated mice on that day (p < 0.05). (B) Parasite burdens in infected feet are shown (mean ± SEM) for mice euthanized on the days indicated: three mice per group up to day 35; after day 35, two mice were pooled (n = 1) . *Indicates a statistically significant difference from vehicle-treated mice on that day (p < 0.02).