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. 2013 Oct 1;8(10):e76259. doi: 10.1371/journal.pone.0076259

Figure 2. TCDD reduces parasite burdens and slows the progression of cutaneous leishmaniasis in SCID mice.

Figure 2

Female SCID mice were treated with peanut oil (vehicle) or TCDD (160 µg/Kg body weight) per os one day prior to infection with one million stationary phase L. major promastigotes in one rear footpad. (A) Lesion size is shown as mean ± SEM for five mice per group. *Indicates a statistically significant difference from vehicle-treated mice on that day (p < 0.05). The results are representative of four separate experiments. (B) Parasite burdens in individual infected feet were analyzed at four weeks post infection (six mice per treatment group; data represent mean ± SEM). Parasite burdens in individual spleens were analyzed at four weeks post infection (three mice per treatment group; data represent mean ± SEM). *Indicates a statistically significant difference from vehicle-treated mice on that day (p < 0.05). The results are representative of 2-3 separate experiments.