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. 2013 Oct 1;8(10):e76259. doi: 10.1371/journal.pone.0076259

Figure 3. Effects of TCDD in SCID mice after low dose infection.

Figure 3

Female SCID mice were treated with peanut oil (vehicle) or TCDD at various doses (per os) one day prior to infection with ten thousand stationary phase L. major promastigotes in one rear footpad. (A) Lesion size is shown as mean ± SEM for 3-5 mice per time point. Symbols with internal plus marks (+) indicate a statistically significant difference from vehicle mice on that day (p < 0.05). All animals within a treatment group were euthanized following the last indicated measurement. (B) Mice were euthanized on the days indicated, and the infected feet of 2-3 mice per group were analyzed as a pool (n=1) for parasite burdens. (C) Percent body weight change is shown as mean ± SEM for 5 mice per time point. Data shown on day 35 reflects body weight change of animals measured either on day 35 or day 37.