Table 1. TCDD treatment decreased body weight and lymph node cell numbers 26 days after L. major infection.
TCDD Treatment |
|||
---|---|---|---|
Vehicle | 160 µg/Kg | p | |
Body weight change (g) | 2.23 ± 0.64 | -0.23 ± 0.32 | 0.03 |
Thymus/Body weight (mg/g) | 2.11 ± 0.36 | 0.91 ± 0.07 | 0.03 |
Total lymph node cells (x 10-6) | 108.6 ± 21.4 | 5.3 ± 0.8 | 0.001 |
Percent CD4+ | 28.3 ± 2.3 | 18.7 ± 3.8 | |
Percent CD4+CD25+ | 12.3 ± 0.9 | 23.0 ± 3.2 | 0.03 |
Percent CD8+ | 13.0 ± 1.0 | 9.7 ± 1.9 | |
Percent CD45R+ | 54.7 ± 2.3 | 58.0 ± 3.5 |
Female wild type BALB/c mice were treated with peanut oil (vehicle) or TCDD (160 µg/Kg per os) one day prior to infection with one million stationary phase L. major promastigotes in one rear footpad. Data represent mean ± SEM for three animals per treatment group.